diff --git a/distribution/changelog.txt b/distribution/changelog.txt
index 8abf55acd8..d067a144f8 100644
--- a/distribution/changelog.txt
+++ b/distribution/changelog.txt
@@ -1,5 +1,6 @@
 0.4.29 (in development)
 ------------------------------------------------------------------------
+- Fix: [#25451] Dropdown item tooltips stay open if the mouse is moved over an empty space.
 
 0.4.28 (2025-11-01)
 ------------------------------------------------------------------------
diff --git a/src/openrct2-ui/input/MouseInput.cpp b/src/openrct2-ui/input/MouseInput.cpp
index 0de2167bfa..b388897cd1 100644
--- a/src/openrct2-ui/input/MouseInput.cpp
+++ b/src/openrct2-ui/input/MouseInput.cpp
@@ -1466,6 +1466,11 @@ namespace OpenRCT2
             int32_t dropdown_index = DropdownIndexFromPoint(screenCoords, w);
             if (dropdown_index == -1)
             {
+                if (gDropdown.hasTooltips && gDropdown.lastTooltipHover != -1)
+                {
+                    gDropdown.lastTooltipHover = -1;
+                    WindowTooltipClose();
+                }
                 return;
             }